Publications

Journal Publication
PLoS genetics

Plasma Cholesterol-Induced Lesion Networks Activated before Regression of Early, Mature, and Advanced Atherosclerosis.

Björkegren JL, Hägg S, Talukdar HA, Foroughi Asl H, Jain RK, Cedergren C, Shang MM, Rossignoli A, Takolander R, Melander O, Hamsten A, Michoel T, Skogsberg J.

PLoS Genet . 2014 Feb 27;10(2):e1004201. doi: 10.1371/journal.pgen.1004201. eCollection 2014 Feb.

Related citations

BMC Bioinformatics

kruX: matrix-based non-parametric eQTL discovery.

Qi J, Asl HF, Björkegren J, Michoel T.

BMC Bioinformatics . 2014 Jan 14;15:11. doi: 10.1186/1471-2105-15-11.

Related citations

Genome medicine

Systems and genome-wide approaches unite to provide a route to personalized medicine.

Stranger BE, Björkegren J, Dolan ME, Ritchie MD.

Genome Med . 2012 Mar 30;4(3):29. [Epub ahead of print]

Related citations

Science translational medicine

NEW: Network-Enabled Wisdom in Biology, Medicine, and Health Care.

Schadt EE, Björkegren JL.

Sci Transl Med . 2012 Jan 4;4(115):115rv1.

Related citations

Journal of lipids

Free PMC Article

Hansen JB, Fernández JA, Notø AT, Deguchi H, Björkegren J, Mathiesen EB.

J Lipids . 2011;2011:271062. Epub 2011 Jul 6.

Related citations Free full text

International journal of molecular medicine

MMP-2 and MMP-9 are prominent matrix metalloproteinases during atherosclerosis development in the Ldlr-/-Apob100/100 mouse.

Wågsäter D, Zhu C, Björkegren J, Skogsberg J, Eriksson P.

Int J Mol Med . 2011 Aug;28(2):247-53. doi: 10.3892/ijmm.2011.693. Epub 2011 May 6.

Related citations

PloS one

Carotid plaque age is a feature of plaque stability inversely related to levels of plasma insulin.

Hägg S, Salehpour M, Noori P, Lundström J, Possnert G, Takolander R, Konrad P, Rosfors S, Ruusalepp A, Skogsberg J, Tegnér J, Björkegren J.

PLoS One . 2011 Apr 7;6(4):e18248.

Related citations

International journal of molecular medicine

Blood levels of dual-specificity phosphatase-1 independently predict risk for post-operative morbidities causing prolonged hospitalization after coronary artery bypass grafting.

Hägg S, Alserius T, Noori P, Ruusalepp A, Ivert T, Tegnér J, Björkegren J, Skogsberg J.

Int J Mol Med . 2011 Jun;27(6):851-7. doi: 10.3892/ijmm.2011.650. Epub 2011 Mar 17.

Related citations

Metabolism: clinical and experimental

Expression of the selenoprotein S (SELS) gene in subcutaneous adipose tissue and SELS genotype are associated with metabolic risk factors.

Olsson M, Olsson B, Jacobson P, Thelle DS, Björkegren J, Walley A, Froguel P, Carlsson LM, Sjöholm K.

Metabolism . 2011 Jan;60(1):114-20.

Related citations Free full text

Arteriosclerosis, thrombosis, and vascular biology

DGAT1 participates in the effect of HNF4A on hepatic secretion of triglyceride-rich lipoproteins.

Krapivner S, Iglesias MJ, Silveira A, Tegnér J, Björkegren J, Hamsten A, van't Hooft FM.

Arterioscler Thromb Vasc Biol . 2010 May;30(5):962-7. Epub 2010 Feb 18.

Related citations

PLoS genetics

Multi-organ expression profiling uncovers a gene module in coronary artery disease involving transendothelial migration of leukocytes and LIM domain binding 2: the Stockholm Atherosclerosis Gene Expression (STAGE) study.

Hägg S, Skogsberg J, Lundström J, Noori P, Nilsson R, Zhong H, Maleki S, Shang MM, Brinne B, Bradshaw M, Bajic VB, Samnegård A, Silveira A, Kaplan LM, Gigante B, Leander K, de Faire U, Rosfors S, Lockowandt U, Liska J, Konrad P, Takolander R, Franco-Cereceda A, Schadt EE, Ivert T, Hamsten A, Tegnér J, Björkegren J.

PLoS Genet . 2009 Dec;5(12):e1000754. Epub 2009 Dec 4.

Related citations Free full text

IET systems biology

Genome-wide system analysis reveals stable yet flexible network dynamics in yeast.

Gustafsson M, Hörnquist M, Björkegren J, Tegnér J.

IET Syst Biol . 2009 Jul;3(4):219-28.

Related citations

Nature genetics

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.

FANTOM Consortium, Suzuki H, Forrest AR, van Nimwegen E, Daub CO, Balwierz PJ, Irvine KM, Lassmann T, Ravasi T, Hasegawa Y, de Hoon MJ, Katayama S, Schroder K, Carninci P, Tomaru Y, Kanamori-Katayama M, Kubosaki A, Akalin A, Ando Y, Arner E, Asada M, Asahara H, Bailey T, Bajic VB, Bauer D, Beckhouse AG, Bertin N, Björkegren J, Brombacher F, Bulger E, Chalk AM, Chiba J, Cloonan N, Dawe A, Dostie J, Engström PG, Essack M, Faulkner GJ, Fink JL, Fredman D, Fujimori K, Furuno M, Gojobori T, Gough J, Grimmond SM, Gustafsson M, Hashimoto M, Hashimoto T, Hatakeyama M, Heinzel S, Hide W, Hofmann O, Hörnquist M, Huminiecki L, Ikeo K, Imamoto N, Inoue S, Inoue Y, Ishihara R, Iwayanagi T, Jacobsen A, Kaur M, Kawaji H, Kerr MC, Kimura R, Kimura S, Kimura Y, Kitano H, Koga H, Kojima T, Kondo S, Konno T, Krogh A, Kruger A, Kumar A, Lenhard B, Lennartsson A, Lindow M, Lizio M, Macpherson C, Maeda N, Maher CA, Maqungo M, Mar J, Matigian NA, Matsuda H, Mattick JS, Meier S, Miyamoto S, Miyamoto-Sato E, Nakabayashi K, Nakachi Y, Nakano M, Nygaard S, Okayama T, Okazaki Y, Okuda-Yabukami H, Orlando V, Otomo J, Pachkov M, Petrovsky N, Plessy C, Quackenbush J, Radovanovic A, Rehli M, Saito R, Sandelin A, Schmeier S, Schönbach C, Schwartz AS, Semple CA, Sera M, Severin J, Shirahige K, Simons C, St Laurent G, Suzuki M, Suzuki T, Sweet MJ, Taft RJ, Takeda S, Takenaka Y, Tan K, Taylor MS, Teasdale RD, Tegnér J, Teichmann S, Valen E, Wahlestedt C, Waki K, Waterhouse A, Wells CA, Winther O, Wu L, Yamaguchi K, Yanagawa H, Yasuda J, Zavolan M, Hume DA; Riken Omics Science Center, Arakawa T, Fukuda S, Imamura K, Kai C, Kaiho A, Kawashima T, Kawazu C, Kitazume Y, Kojima M, Miura H, Murakami K, Murata M, Ninomiya N, Nishiyori H, Noma S, Ogawa C, Sano T, Simon C, Tagami M, Takahashi Y, Kawai J, Hayashizaki Y.

Nat Genet . 2009 May;41(5):553-62. Epub 2009 Apr 19.

Related citations

Annals of the New York Academy of Sciences

Reverse engineering of gene networks with LASSO and nonlinear basis functions.

Gustafsson M, Hörnquist M, Lundström J, Björkegren J, Tegnér J.

Ann N Y Acad Sci . 2009 Mar;1158:265-75.

Related citations

IET systems biology

Deconstructing the core dynamics from a complex time-lagged regulatory biological circuit.

Eriksson O, Brinne B, Zhou Y, Björkegren J, Tegnér J.

IET Syst Biol . 2009 Mar;3(2):113-29.

Related citations

BMC bioinformatics

On reliable discovery of molecular signatures.

Nilsson R, Björkegren J, Tegnér J.

BMC Bioinformatics . 2009 Jan 29;10:38.

Related citations Free full text

PloS one

ApoB100-LDL acts as a metabolic signal from liver to peripheral fat causing inhibition of lipolysis in adipocytes.

Skogsberg J, Dicker A, Rydén M, Aström G, Nilsson R, Bhuiyan H, Vitols S, Mairal A, Langin D, Alberts P, Walum E, Tegnér J, Hamsten A, Arner P, Björkegren J.

PLoS One . 2008;3(11):e3771. Epub 2008 Nov 20.

Related citations Free full text

Lipids

The ApoC-I content of VLDL particles is associated with plaque size in persons with carotid atherosclerosis.

Notø AT, Mathiesen EB, Brox J, Björkegren J, Hansen JB.

Lipids . 2008 Jul;43(7):673-9. Epub 2008 May 29.

Related citations

PLoS genetics

Transcriptional profiling uncovers a network of cholesterol-responsive atherosclerosis target genes.

Skogsberg J, Lundström J, Kovacs A, Nilsson R, Noori P, Maleki S, Köhler M, Hamsten A, Tegnér J, Björkegren J.

PLoS Genet . 2008 Mar 14;4(3):e1000036.

Related citations Free full text

Lipids

Delayed metabolism of postprandial triglyceride-rich lipoproteins in subjects with echolucent carotid plaques.

Notø AT, Mathiesen EB, Brox J, Björkegren J, Hansen JB.

Lipids . 2008 Apr;43(4):353-60. Epub 2008 Mar 5.

Related citations

Bioinformatics and biology insights

Evidence of highly regulated genes (in-Hubs) in gene networks of Saccharomyces cerevisiae.

Lundström J, Björkegren J, Tegnér J.

Bioinform Biol Insights . 2008 Jul 14;2:307-16.

Related citations Free full text

Lakartidningen

[Systems biology makes detailed understanding of complex diseases possible. Arteriosclerosis is an example].

Björkegren J, Tegnér J.

Lakartidningen . 2007 Oct 17-23;104(42):3042-5. Review. Swedish. No abstract available.

Related citations

Clinical endocrinology

Correlation of serum IGF-I and IGFBP-1 and -3 to cardiovascular risk indicators and early carotid atherosclerosis in healthy middle-aged men.

Boquist S, Ruotolo G, Skoglund-Andersson C, Tang R, Björkegren J, Bond MG, de Faire U, Brismar K, Hamsten A.

Clin Endocrinol (Oxf) . 2008 Jan;68(1):51-8. Epub 2007 Sep 4.

Related citations

Proceedings of the National Academy of Sciences of the United States of America

Human C-reactive protein slows atherosclerosis development in a mouse model with human-like hypercholesterolemia.

Kovacs A, Tornvall P, Nilsson R, Tegnér J, Hamsten A, Björkegren J.

Proc Natl Acad Sci U S A . 2007 Aug 21;104(34):13768-73. Epub 2007 Aug 16.

Related citations Free full text

Atherosclerosis

ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques.

Wågsäter D, Björk H, Zhu C, Björkegren J, Valen G, Hamsten A, Eriksson P.

Atherosclerosis . 2008 Feb;196(2):514-22. Epub 2007 Jul 2.

Related citations

BMC bioinformatics

Detecting multivariate differentially expressed genes.

Nilsson R, Peña JM, Björkegren J, Tegnér J.

BMC Bioinformatics . 2007 May 9;8:150.

Related citations Free full text

Cellular immunology

Systems biology of innate immunity.

Tegnér J, Nilsson R, Bajic VB, Björkegren J, Ravasi T.

Cell Immunol . 2006 Dec;244(2):105-9. Epub 2007 Apr 11.

Related citations Free full text

Journal of lipid research

Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Multi-organ whole-genome measurements and reverse engineering to uncover gene networks underlying complex traits.

Tegnér J, Skogsberg J, Björkegren J.

J Lipid Res . 2007 Feb;48(2):267-77. Epub 2006 Dec 1. Review.

Related citations

Trends in genetics : TIG

Perturbations to uncover gene networks.

Tegnér J, Björkegren J.

Trends Genet . 2007 Jan;23(1):34-41. Epub 2006 Nov 13. Review.

Related citations

Genomics

Transcriptional network dynamics in macrophage activation.

Nilsson R, Bajic VB, Suzuki H, di Bernardo D, Björkegren J, Katayama S, Reid JF, Sweet MJ, Gariboldi M, Carninci P, Hayashizaki Y, Hume DA, Tegner J, Ravasi T.

Genomics . 2006 Aug;88(2):133-42. Epub 2006 May 12.

Related citations

Current atherosclerosis reports

Dual roles of apolipoprotein CI in the formation of atherogenic remnants.

Björkegren J.

Curr Atheroscler Rep . 2006 Jan;8(1):1-2. No abstract available.

Related citations

BMC bioinformatics

Detection of compound mode of action by computational integration of whole-genome measurements and genetic perturbations.

Hallén K, Björkegren J, Tegnér J.

BMC Bioinformatics . 2006 Feb 2;7:51.

Related citations Free full text