CVG on the cover of Science
Welcome to the Cardiovascular Genomics group
The main goal of our research is to define regulatory tissue and cross-tissue gene networks underlying coronary artery disease (CAD) and myocardial infarction (MI). This is being achieved by gathering –omics datasets from well-characterized patient cohorts and model systems of atherosclerosis. We particularly focus on regulatory networks important for cross-talk between organs, which are believed to play a central role in CAD.
We foresee that molecular networks will provide the foundation on which preventive, predictive and personalized cardiovascular care can be built. Besides providing clues to the most efficient targets for novel CAD/MI drugs, these networks are essential to understand the CAD/MI risk situation in any given individual.
Please click around our Website and if you become interested do not hesitate to make contact!
2014-09-05 - From Hairballs to Understanding Atherosclerosis
New publication form CVG group in Atherosclerosis Thrombosis and Vascular Biology with an Editorial comment by Mette Civelek and Jake Lusis. "In the July issue of ATVB, Shang et al provide compelling evidence for the involvement of LIM domain binding 2 (LDB2) in the transendothelial migration of monocytes in atherosclerosis. The article is also of interest because of the systems analyses that led to its identification as a strong candidate. The results presented in this article provide validation of the value of the approach as well as the role of the gene"
Plasma Cholesterol-Induced Lesion Networks Activated before Regression of Early, Mature, and Advanced Atherosclerosis.
PLoS Genet . 2014 Feb 27;10(2):e1004201. doi: 10.1371/journal.pgen.1004201. eCollection 2014 Feb.
Sci Transl Med . 2012 Jan 4;4(115):115rv1.
PLoS One . 2011 Apr 7;6(4):e18248.
Multi-organ expression profiling uncovers a gene module in coronary artery disease involving transendothelial migration of leukocytes and LIM domain binding 2: the Stockholm Atherosclerosis Gene Expression (STAGE) study.
PLoS Genet . 2009 Dec;5(12):e1000754. Epub 2009 Dec 4.